TQ Quiz | Game Changers: Therapeutic Innovations (Charleston 2025)

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1. Which of the following medications is a preservative-free prostaglandin analog?*

A - Travatan Z (travoprost ophthalmic solution) 0.004%

B - Iyuzeh (latanoprost ophthalmic solution) 0.005%

C - Lumigan (bimatoprost ophthalmic solution) 0.01%

D - Vyzulta (latanoprostene bunod ophthalmic solution) 0.024%

2. Rocklatan (netarsudil 0.02%/latanoprost 0.005%) dosage is correctly described as:*

A - Every other day

B - Once daily in the evening

C - Twice daily

D - Three times daily

3. Current treatment options for presbyopia include which of the following classes of medications?*

A - Beta blockers

B - Cholinergics

C - Steroids

D - Fluoroquinolones

4. What is the name of the FDA-approved dual-pathway inhibiting agent for the treatment of neovascular macular degeneration, diabetic macular edema, and macular edema following retinal vein occlusion?*

A - Faricimab

B - Tocilizumab

C - Teprotumumab

D - Bevacizumab

5. Possible adverse effects of intravitreal anti-VEGF injection include all but which of the following?*

A - Elevated intraocular pressure

B - Endophthalmitis

C - Subconjunctival hemorrhage

D - Myopia

6. Syfovre (pegcetacoplan) is FDA approved for the treatment of:*

A - Neovascular AMD

B - Geographic atrophy

C - Intermediate stage non-exudative AMD

D - Cystoid macular edema

7. Long-term use of topical ocular medications preserved with benzalkonium chloride (BAK) may cause which of the following?*

A - Decreased goblet cell density

B - Increased intraocular pressure

C - Cystoid macular edema

D - Hyperopic shift

8. Activation of the complement system ultimately leads to which cellular process?*

A - Apoptosis

B - Mitosis

C - Respiration

D - Transcription

9. FDA-approved biosimilars are available for which of the following anti-VEGF agents?*

A - Ranibizumab

B - Axitinib

C - Brolucizumab

D - Faricimab

10. Effects related to reversal of pharmacologic mydriasis with phentolamine 0.75% (Ryzumvi) were achieved approximately how quickly following instillation in clinical trials?*

A - 10 minutes

B - 60 minutes

C - 2 hours

D - 6 hours

11. Lotilaner 0.25% (Xdemvy) is on-label for the treatment of:*

A - Signs and symptoms of dry eye disease

B - Allergic conjunctivitis

C - Reversal of mydriasis

D - Demodex blepharitis

12. All of the following are anti-VEGF agents, EXCEPT:*

A - Eylea

B - Lucentis

C - Iluvien

D - Avastin

13. What is the difference between generic latanoprost 0.005% and Iyuzeh (latanoprost ophthalmic solution 0.005%)?*

A - Mechanism of action

B - Preservative

C - Active ingredient

D - Dosage

14. What is the primary mechanism of action of rho-kinase inhibitors?*

A - Increased uveoscleral outflow

B - Decreased aqueous production

C - Increased trabecular outflow

D - Increased episcleral venous pressure

15. Which topical ophthalmic IOP-lowering medication contains a nitric-oxide donating moiety?*

A - Latanoprostene bunod 0.024% (Vyzulta)

B - Netarsudil 0.02% (Rhopressa)

C - Dorzolamide 2%

D - Preservative-free latanoprost 0.005% (Iyuzeh)

16. The correct dosing of Vevye (cyclosporine ophthalmic solution) 0.1% is described as:*

A - Once daily

B - Twice daily

C - Three times daily

D - Four times daily

17. What is the mechanism of action of varenicline nasal spray in the treatment of signs and symptoms of dry eye disease?*

A - Reduces tear film evaporation

B - Inhibits cytokine release

C - Acts as an antiparasitic agent

D - Activates the trigeminal parasympathetic pathway

18. Why is lotilaner 0.25% (Xdemv) labeled for 6 weeks of treatment for Demodex blepharitis?*

A - To match the lifecycle of Demodex mites

B - To align with insurance coverage policies

C - To reduce the need for preservative-free formulations

D - To maximize adherence to treatment

19. How does the Valeda light delivery system function in dry AMD treatment?*

A - Inhibits VEGF pathways

B - Uses photobiomodulation to stimulate mitochondrial function

C - Targets complement inhibition

D - Acts as a rho kinase inhibitor

20. What is the mechanism of action for 100% perfluorohexyloctane (Miebo) in the treatment of the signs and symptoms of dry eye disease?*

A - Increased tear production

B - Stabilization of the tear film and reduces evaporation

C - Inhibition of complement activation

D - Reduction in intraocular pressure

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